Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids

• Main Authors: Donatella Fiore (Author), Prashanthi Ramesh (Author), Maria C. Proto (Author), Chiara Piscopo (Author), Silvia Franceschelli (Author), Serena Anzelmo (Author), Jan P. Medema (Author), Maurizio Bifulco (Author), Patrizia Gazzerro (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal cancer (CRC), like other tumor types, is a highly heterogeneous disease. Within the tumor bulk, intra-tumoral heterogeneity is also ascribable to Cancer Stem Cells (CSCs) subpopulation, characterized by high chemoresistance and the unique ability to retain tumorigenic potential, thus asso...