Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization

• Principais autores: Carmelo Puglia (Autor), Debora Santonocito (Autor), Angela Bonaccorso (Autor), Teresa Musumeci (Autor), Barbara Ruozi (Autor), Rosario Pignatello (Autor), Claudia Carbone (Autor), Carmela Parenti (Autor), Santina Chiechio (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2020-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Background: Capsaicin (CPS) is a highly selective agonist of the transient receptor potential vanilloid type 1 (TRPV1) with a nanomolar affinity. High doses or prolonged exposure to CPS induces TRPV1 defunctionalization and, although this effect is currently used for the treatment of thermal hyperal...