Endothelial Thioredoxin-Interacting Protein Depletion Reduces Hemorrhagic Transformation in Hyperglycemic Mice after Embolic Stroke and Thrombolytic Therapy

• Auteurs principaux: Mohd. Salman (Auteur), Saifudeen Ismael (Auteur), Lexiao Li (Auteur), Heba A. Ahmed (Auteur), Michelle A. Puchowicz (Auteur), Tauheed Ishrat (Auteur)
• Format: Livre
• Publié: MDPI AG, 2021-09-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

We hypothesize that endothelial-specific thioredoxin-interacting protein knock-out (EC-TXNIP KO) mice will be more resistant to the neurovascular damage (hemorrhagic-transformation-HT) associated with hyperglycemia (HG) in embolic stroke. Adult-male EC-TXNIP KO and wild-type (WT) littermate mice wer...