Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.

• Main Authors: Eliana A G Reis (Author), José E Hagan (Author), Guilherme S Ribeiro (Author), Andrea Teixeira-Carvalho (Author), Olindo A Martins-Filho (Author), Ruth R Montgomery (Author), Albert C Shaw (Author), Albert I Ko (Author), Mitermayer G Reis (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>The role of the immune response in influencing leptospirosis clinical outcomes is not yet well understood. We hypothesized that acute-phase serum cytokine responses may play a role in disease progression, risk for death, and severe pulmonary hemorrhage syndrome (SPHS)....