Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury

• Asıl Yazarlar: Hitoshi Uchida (Yazar), Yosuke Matsushita (Yazar), Kohei Araki (Yazar), Takehiro Mukae (Yazar), Hiroshi Ueda (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2015-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Neuropathic pain is often insensitive to morphine. Our previous study has demonstrated that neuron-restrictive silencer factor represses mu opioid receptor (MOP) gene expression in the dorsal root ganglion (DRG) via histone hypoacetylation-mediated mechanisms after peripheral nerve injury, thereby c...