Histone deacetylase inhibitors relieve morphine resistance in neuropathic pain after peripheral nerve injury

• প্রধান লেখক: Hitoshi Uchida (লেখক), Yosuke Matsushita (লেখক), Kohei Araki (লেখক), Takehiro Mukae (লেখক), Hiroshi Ueda (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2015-08-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Neuropathic pain is often insensitive to morphine. Our previous study has demonstrated that neuron-restrictive silencer factor represses mu opioid receptor (MOP) gene expression in the dorsal root ganglion (DRG) via histone hypoacetylation-mediated mechanisms after peripheral nerve injury, thereby c...