β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs

• Main Authors: Sara Ibrahim (Author), Macey Johnson (Author), Clarissa Hernandez Stephens (Author), Jerry Xu (Author), Rachel Moore (Author), Andrea Mariani (Author), Christopher Contreras (Author), Farooq Syed (Author), Raghavendra G. Mirmira (Author), Ryan M. Anderson (Author), Emily K. Sims (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: β-cell microRNA-21 (miR-21) is increased by islet inflammatory stress but it decreases glucose-stimulated insulin secretion (GSIS). Thus, we sought to define the effects of miR-21 on β-cell function using in vitro and in vivo systems. Methods: We developed a tetracycline-on system of pre-...