β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs

• मुख्य लेखकों: Sara Ibrahim (लेखक), Macey Johnson (लेखक), Clarissa Hernandez Stephens (लेखक), Jerry Xu (लेखक), Rachel Moore (लेखक), Andrea Mariani (लेखक), Christopher Contreras (लेखक), Farooq Syed (लेखक), Raghavendra G. Mirmira (लेखक), Ryan M. Anderson (लेखक), Emily K. Sims (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2021-11-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: β-cell microRNA-21 (miR-21) is increased by islet inflammatory stress but it decreases glucose-stimulated insulin secretion (GSIS). Thus, we sought to define the effects of miR-21 on β-cell function using in vitro and in vivo systems. Methods: We developed a tetracycline-on system of pre-...