Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review

• Главные авторы: Paolo E Porporato (Автор), Rajesh K Dadhich (Автор), Suveera eDhup (Автор), Tamara eCopetti (Автор), Pierre eSonveaux (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2011-08-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Cancer is a metabolic disease and the solution of two metabolic equations: to produce energy with limited resources and to fulfill the biosynthetic needs of proliferating cells. Both equations are solved when glycolysis is uncoupled from oxidative phosphorylation in the tricarboxylic acid cycle, a p...