Molecular Disorder of Bicalutamide-Amorphous Solid Dispersions Obtained by Solvent Methods

• Main Authors: Joanna Szafraniec (Author), Agata Antosik (Author), Justyna Knapik-Kowalczuk (Author), Karolina Gawlak (Author), Mateusz Kurek (Author), Jakub Szlęk (Author), Witold Jamróz (Author), Marian Paluch (Author), Renata Jachowicz (Author)
• Format: Book
• Published: MDPI AG, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effect of solvent removal techniques on phase transition, physical stability and dissolution of bicalutamide from solid dispersions containing polyvinylpyrrolidone (PVP) as a carrier was investigated. A spray dryer and a rotavapor were applied to obtain binary systems containing either 50% or 66...