Molecular Disorder of Bicalutamide-Amorphous Solid Dispersions Obtained by Solvent Methods

• Váldodahkkit: Joanna Szafraniec (Dahkki), Agata Antosik (Dahkki), Justyna Knapik-Kowalczuk (Dahkki), Karolina Gawlak (Dahkki), Mateusz Kurek (Dahkki), Jakub Szlęk (Dahkki), Witold Jamróz (Dahkki), Marian Paluch (Dahkki), Renata Jachowicz (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2018-10-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The effect of solvent removal techniques on phase transition, physical stability and dissolution of bicalutamide from solid dispersions containing polyvinylpyrrolidone (PVP) as a carrier was investigated. A spray dryer and a rotavapor were applied to obtain binary systems containing either 50% or 66...