Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXRα and Suppresses the Expression of PXR, CAR and Their Target Genes

• Autores principales: Rui Ning (Autor), Yunran Zhan (Autor), Shuangcheng He (Autor), Jinhua Hu (Autor), Zhu Zhu (Autor), Gang Hu (Autor), Bingfang Yan (Autor), Jian Yang (Autor), Wei Liu (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Inflammatory burden is a primary cellular event in many liver diseases, and the overall capacity of drug elimination is decreased. PXR (pregnane X receptor) and CAR (constitutive androstane receptor) are two master regulators of genes encoding drug-metabolizing enzymes and transporters. DEC1 (differ...