Interleukin-6 Induces DEC1, Promotes DEC1 Interaction with RXRα and Suppresses the Expression of PXR, CAR and Their Target Genes

• Main Authors: Rui Ning (Author), Yunran Zhan (Author), Shuangcheng He (Author), Jinhua Hu (Author), Zhu Zhu (Author), Gang Hu (Author), Bingfang Yan (Author), Jian Yang (Author), Wei Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammatory burden is a primary cellular event in many liver diseases, and the overall capacity of drug elimination is decreased. PXR (pregnane X receptor) and CAR (constitutive androstane receptor) are two master regulators of genes encoding drug-metabolizing enzymes and transporters. DEC1 (differ...