Reduced variability in tacrolimus pharmacokinetics following intramuscular injection compared to oral administration in cynomolgus monkeys: Investigating optimal dosing regimens

• Главные авторы: Kyo Won Lee (Автор), Tae Hwan Kim (Автор), Jong Bong Lee (Автор), Kyeong Sik Kim (Автор), Jae Berm Park (Автор), Pavel Gershkovich (Автор), Sun Dong Yoo (Автор), Soyoung Shin (Автор), Beom Soo Shin (Автор), Sung Joo Kim (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2019-02-01T00:00:00Z.
• Предметы: article
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Tacrolimus is one of the most commonly used immunosuppressive agents in animal models of transplantation. However, in these models, oral administration is often problematic due to the lowered compliance associated with highly invasive surgery and due to malabsorption in the intestinal tract. Therefo...