Evaluation of Approaches for the Assessment of HER2 Expression in Breast Cancer by Radionuclide Imaging Using the Scaffold Protein [^99mTc]Tc-ADAPT6

• Main Authors: Olga Bragina (Author), Liubov Tashireva (Author), Dmitriy Loos (Author), Vladimir Chernov (Author), Sophia Hober (Author), Vladimir Tolmachev (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Due to its small size and high affinity binding, the engineered scaffold protein ADAPT6 is a promising targeting probe for radionuclide imaging of human epidermal growth factor receptor type 2 (HER2). In a Phase I clinical trial, [^99mTc]Tc-ADAPT6 demonstrated safety, tolerabil...