Effects of Protein Kinase A on the Phosphorylation Status and Transverse Stiffness of Cardiac Myofibrils

• Main Authors: Yoshiki Ohnuki (Author), Takenori Yamada (Author), Yasumasa Mototani (Author), Daisuke Umeki (Author), Kouichi Shiozawa (Author), Takayuki Fujita (Author), Yasutake Saeki (Author), Satoshi Okumura (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stimulation of β-adrenergic receptors in cardiac myocytes activates cyclic AMP- dependent protein kinase A (PKA). PKA-mediated phosphorylation of myofibrils decreases their longitudinal stiffness, but its effect on transverse stiffness is not fully understood. We thus examined the effects of PKA tre...