Insights on the conformation and appropriate drug-target sites on retinal IMPDH1 using the 604-aa isoform lacking the C-terminal extension

• প্রধান লেখক: Parisa Elyasi-Ebli (লেখক), Razieh Yazdanparast (লেখক), Sajjad Gharaghani (লেখক), Ebrahim Barzegari (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Background and purpose: Retinitis pigmentosa (RP) accounts for 2 percent of global cases of blindness. The RP10 form of the disease results from mutations in isoform 1 of inosine 5'-monophosphate dehydrogenase (IMPDH1), the rate-limiting enzyme in the de novo purine nucleotide synthesis pathway...