Insights on the conformation and appropriate drug-target sites on retinal IMPDH1 using the 604-aa isoform lacking the C-terminal extension

• Автори: Parisa Elyasi-Ebli (Автор), Razieh Yazdanparast (Автор), Sajjad Gharaghani (Автор), Ebrahim Barzegari (Автор)
• Формат: Книга
• Опубліковано: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Background and purpose: Retinitis pigmentosa (RP) accounts for 2 percent of global cases of blindness. The RP10 form of the disease results from mutations in isoform 1 of inosine 5'-monophosphate dehydrogenase (IMPDH1), the rate-limiting enzyme in the de novo purine nucleotide synthesis pathway...