Insights on the conformation and appropriate drug-target sites on retinal IMPDH1 using the 604-aa isoform lacking the C-terminal extension

Background and purpose: Retinitis pigmentosa (RP) accounts for 2 percent of global cases of blindness. The RP10 form of the disease results from mutations in isoform 1 of inosine 5'-monophosphate dehydrogenase (IMPDH1), the rate-limiting enzyme in the de novo purine nucleotide synthesis pathway...

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Main Authors: Parisa Elyasi-Ebli (Author), Razieh Yazdanparast (Author), Sajjad Gharaghani (Author), Ebrahim Barzegari (Author)
Format: Book
Published: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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