Insights on the conformation and appropriate drug-target sites on retinal IMPDH1 using the 604-aa isoform lacking the C-terminal extension

• Asıl Yazarlar: Parisa Elyasi-Ebli (Yazar), Razieh Yazdanparast (Yazar), Sajjad Gharaghani (Yazar), Ebrahim Barzegari (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wolters Kluwer Medknow Publications, 2023-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Background and purpose: Retinitis pigmentosa (RP) accounts for 2 percent of global cases of blindness. The RP10 form of the disease results from mutations in isoform 1 of inosine 5'-monophosphate dehydrogenase (IMPDH1), the rate-limiting enzyme in the de novo purine nucleotide synthesis pathway...