Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson's Disease-Linked PARK7

• Главные авторы: Takashi Yanagida (Автор), Yoshihisa Kitamura (Автор), Koichiro Yamane (Автор), Kazunori Takahashi (Автор), Kazuyuki Takata (Автор), Daijiro Yanagisawa (Автор), Hiroyuki Yasui (Автор), Takashi Taniguchi (Автор), Takahiro Taira (Автор), Toshio Honda (Автор), Hiroyoshi Ariga (Автор)
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• Опубликовано: Elsevier, 2009-01-01T00:00:00Z.
• Предметы: article
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Although a loss-of-function type mutation was identified in familial Parkinson's disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we found a DJ-1 modulator UCP0054278 by in silico virtual screening. In this study, we determined the...