Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson's Disease-Linked PARK7

• Main Authors: Takashi Yanagida (Author), Yoshihisa Kitamura (Author), Koichiro Yamane (Author), Kazunori Takahashi (Author), Kazuyuki Takata (Author), Daijiro Yanagisawa (Author), Hiroyuki Yasui (Author), Takashi Taniguchi (Author), Takahiro Taira (Author), Toshio Honda (Author), Hiroyoshi Ariga (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although a loss-of-function type mutation was identified in familial Parkinson's disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we found a DJ-1 modulator UCP0054278 by in silico virtual screening. In this study, we determined the...