Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.

• المؤلفون الرئيسيون: Suélen Fernandes Silva (مؤلف), Angélica Hollunder Klippel (مؤلف), Priscila Zonzini Ramos (مؤلف), André da Silva Santiago (مؤلف), Sandro Roberto Valentini (مؤلف), Mario Henrique Bengtson (مؤلف), Katlin Brauer Massirer (مؤلف), Elizabeth Bilsland (مؤلف), Rafael Miguez Couñago (مؤلف), Cleslei Fernando Zanelli (مؤلف)
• التنسيق: كتاب
• منشور في: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Deoxyhypusine synthase (DHS) catalyzes the first step of the post-translational modification of eukaryotic translation factor 5A (eIF5A), which is the only known protein containing the amino acid hypusine. Both proteins are essential for eukaryotic cell viability, and DHS has been suggested as a goo...