Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.

• প্রধান লেখক: Suélen Fernandes Silva (লেখক), Angélica Hollunder Klippel (লেখক), Priscila Zonzini Ramos (লেখক), André da Silva Santiago (লেখক), Sandro Roberto Valentini (লেখক), Mario Henrique Bengtson (লেখক), Katlin Brauer Massirer (লেখক), Elizabeth Bilsland (লেখক), Rafael Miguez Couñago (লেখক), Cleslei Fernando Zanelli (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Deoxyhypusine synthase (DHS) catalyzes the first step of the post-translational modification of eukaryotic translation factor 5A (eIF5A), which is the only known protein containing the amino acid hypusine. Both proteins are essential for eukaryotic cell viability, and DHS has been suggested as a goo...