Structural features and development of an assay platform of the parasite target deoxyhypusine synthase of Brugia malayi and Leishmania major.

• मुख्य लेखकों: Suélen Fernandes Silva (लेखक), Angélica Hollunder Klippel (लेखक), Priscila Zonzini Ramos (लेखक), André da Silva Santiago (लेखक), Sandro Roberto Valentini (लेखक), Mario Henrique Bengtson (लेखक), Katlin Brauer Massirer (लेखक), Elizabeth Bilsland (लेखक), Rafael Miguez Couñago (लेखक), Cleslei Fernando Zanelli (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Deoxyhypusine synthase (DHS) catalyzes the first step of the post-translational modification of eukaryotic translation factor 5A (eIF5A), which is the only known protein containing the amino acid hypusine. Both proteins are essential for eukaryotic cell viability, and DHS has been suggested as a goo...