Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum.

• Main Authors: John B Patton (Author), Sasisekhar Bennuru (Author), Mark L Eberhard (Author), Jessica A Hess (Author), April Torigian (Author), Sara Lustigman (Author), Thomas B Nutman (Author), David Abraham (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>The study of Onchocerca volvulus has been limited by its host range, with only humans and non-human primates shown to be susceptible to the full life cycle infection. Small animal models that support the development of adult parasites have not been identified.<h4>...