A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition

• Váldodahkkit: Hyeongki Kim (Dahkki), Kyu-Sun Lee (Dahkki), Ae-Kyeong Kim (Dahkki), Miri Choi (Dahkki), Kwangman Choi (Dahkki), Mingu Kang (Dahkki), Seung-Wook Chi (Dahkki), Min-Sung Lee (Dahkki), Jeong-Soo Lee (Dahkki), So-Young Lee (Dahkki), Woo-Joo Song (Dahkki), Kweon Yu (Dahkki), Sungchan Cho (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: The Company of Biologists, 2016-08-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

DYRK1A is important in neuronal development and function, and its excessive activity is considered a significant pathogenic factor in Down syndrome and Alzheimer's disease. Thus, inhibition of DYRK1A has been suggested to be a new strategy to modify the disease. Very few compounds, however, hav...