A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition

• Main Authors: Hyeongki Kim (Author), Kyu-Sun Lee (Author), Ae-Kyeong Kim (Author), Miri Choi (Author), Kwangman Choi (Author), Mingu Kang (Author), Seung-Wook Chi (Author), Min-Sung Lee (Author), Jeong-Soo Lee (Author), So-Young Lee (Author), Woo-Joo Song (Author), Kweon Yu (Author), Sungchan Cho (Author)
• Format: Book
• Published: The Company of Biologists, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DYRK1A is important in neuronal development and function, and its excessive activity is considered a significant pathogenic factor in Down syndrome and Alzheimer's disease. Thus, inhibition of DYRK1A has been suggested to be a new strategy to modify the disease. Very few compounds, however, hav...