Multiple mitochondrial introgression events and heteroplasmy in trypanosoma cruzi revealed by maxicircle MLST and next generation sequencing.

• Main Authors: Louisa A Messenger (Author), Martin S Llewellyn (Author), Tapan Bhattacharyya (Author), Oscar Franzén (Author), Michael D Lewis (Author), Juan David Ramírez (Author), Hernan J Carrasco (Author), Björn Andersson (Author), Michael A Miles (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial DNA is a valuable taxonomic marker due to its relatively fast rate of evolution. In Trypanosoma cruzi, the causative agent of Chagas disease, the mitochondrial genome has a unique structural organization consisting of 20-50 maxicircles (∼20 kb) and thousands of minicircles (0.5-10 kb)....