Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo

• मुख्य लेखकों: Simone Mester (लेखक), Mitchell Evers (लेखक), Saskia Meyer (लेखक), Jeannette Nilsen (लेखक), Victor Greiff (लेखक), Inger Sandlie (लेखक), Jeanette Leusen (लेखक), Jan Terje Andersen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin. A prerequisite for such design is that the ABD-albumin interaction does not interfere...