Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo

• Main Authors: Simone Mester (Author), Mitchell Evers (Author), Saskia Meyer (Author), Jeannette Nilsen (Author), Victor Greiff (Author), Inger Sandlie (Author), Jeanette Leusen (Author), Jan Terje Andersen (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin. A prerequisite for such design is that the ABD-albumin interaction does not interfere...