Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo

• Autori principali: Simone Mester (Autore), Mitchell Evers (Autore), Saskia Meyer (Autore), Jeannette Nilsen (Autore), Victor Greiff (Autore), Inger Sandlie (Autore), Jeanette Leusen (Autore), Jan Terje Andersen (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Albumin has a serum half-life of 3 weeks in humans. This feature can be used to improve the pharmacokinetics of shorter-lived biologics. For instance, an albumin-binding domain (ABD) can be used to recruit albumin. A prerequisite for such design is that the ABD-albumin interaction does not interfere...