Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels

• Main Authors: Laila M. Al-Harbi (Author), Eman A. Al-Harbi (Author), Rawda M. Okasha (Author), R. A. El-Eisawy (Author), Mohammed A. A. El-Nassag (Author), Hany M. Mohamed (Author), Ahmed M. Fouda (Author), Ahmed A. Elhenawy (Author), Ahmed Mora (Author), Ahmed M. El-Agrody (Author), Heba K. A. El-Mawgoud (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 1H-benzo[f]chromene moieties (4a-z) were synthesised under Ultrasonic irradiation and confirmed with spectral analyses. Derivative 4i solely possessed an X-ray single crystal. The anti-proliferative efficacy of the desired molecules has been explored against three cancer cells: MCF-7, HC...