Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels

• Egile Nagusiak: Laila M. Al-Harbi (Egilea), Eman A. Al-Harbi (Egilea), Rawda M. Okasha (Egilea), R. A. El-Eisawy (Egilea), Mohammed A. A. El-Nassag (Egilea), Hany M. Mohamed (Egilea), Ahmed M. Fouda (Egilea), Ahmed A. Elhenawy (Egilea), Ahmed Mora (Egilea), Ahmed M. El-Agrody (Egilea), Heba K. A. El-Mawgoud (Egilea)
• Formatua: Liburua
• Argitaratua: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

A series of 1H-benzo[f]chromene moieties (4a-z) were synthesised under Ultrasonic irradiation and confirmed with spectral analyses. Derivative 4i solely possessed an X-ray single crystal. The anti-proliferative efficacy of the desired molecules has been explored against three cancer cells: MCF-7, HC...