Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P-glycoprotein expression levels

• Prif Awduron: Laila M. Al-Harbi (Awdur), Eman A. Al-Harbi (Awdur), Rawda M. Okasha (Awdur), R. A. El-Eisawy (Awdur), Mohammed A. A. El-Nassag (Awdur), Hany M. Mohamed (Awdur), Ahmed M. Fouda (Awdur), Ahmed A. Elhenawy (Awdur), Ahmed Mora (Awdur), Ahmed M. El-Agrody (Awdur), Heba K. A. El-Mawgoud (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

A series of 1H-benzo[f]chromene moieties (4a-z) were synthesised under Ultrasonic irradiation and confirmed with spectral analyses. Derivative 4i solely possessed an X-ray single crystal. The anti-proliferative efficacy of the desired molecules has been explored against three cancer cells: MCF-7, HC...