Novel and Practical Industrial Process Scale-Up of 5-Bromo-2-chloro-4-(methoxycarbonyl)benzoic acid, a Key Intermediate in the Manufacturing of Therapeutic SGLT2 Inhibitors

• Principais autores: Yi Zhang (Autor), Xiao Ma (Autor), Xiao-Hui Shan (Autor), Xiao-Wen Zhang (Autor), Jian-Qi Li (Autor), Yu Liu (Autor)
• Formato: Livro
• Publicado em: Georg Thieme Verlag KG, 2022-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract 5-Bromo-2-chloro-4-(methoxycarbonyl)benzoic acid (1) is a key intermediate for the synthesis of a family of promising SGLT2 inhibitors currently in preclinical and phase I studies for diabetes therapy. In this investigation, cheap, easily available dimethyl terephthalate was used as the raw...