Novel and Practical Industrial Process Scale-Up of 5-Bromo-2-chloro-4-(methoxycarbonyl)benzoic acid, a Key Intermediate in the Manufacturing of Therapeutic SGLT2 Inhibitors

• Main Authors: Yi Zhang (Author), Xiao Ma (Author), Xiao-Hui Shan (Author), Xiao-Wen Zhang (Author), Jian-Qi Li (Author), Yu Liu (Author)
• Format: Knjiga
• Izdano: Georg Thieme Verlag KG, 2022-12-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract 5-Bromo-2-chloro-4-(methoxycarbonyl)benzoic acid (1) is a key intermediate for the synthesis of a family of promising SGLT2 inhibitors currently in preclinical and phase I studies for diabetes therapy. In this investigation, cheap, easily available dimethyl terephthalate was used as the raw...