Searching for a long-acting injectable formulation for the antiretroviral dolutegravir

• Main Authors: Anderson Aparecido de Marchi (Author), Claudia Bandeira Kobarg (Author), Keity Margareth Doretto (Author), Luis Gustavo Robello (Author), Maiara Cássia Pigatto (Author), Marilene Alves (Author), Renar Pereira Santos Pereira (Author)
• Format: Book
• Published: University of Huddersfield Press, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to engineer a DTG particle size able to provide plasma drug concentration maintenance above PA-IC-90 and, based on such drug prolonged- exposure, to evaluate the 30 days-acting injectable DTG feasibility for anti-HIV therapy. Liquid antisolvent precipitation technology was...