Searching for a long-acting injectable formulation for the antiretroviral dolutegravir

• 主要な著者: Anderson Aparecido de Marchi (著者), Claudia Bandeira Kobarg (著者), Keity Margareth Doretto (著者), Luis Gustavo Robello (著者), Maiara Cássia Pigatto (著者), Marilene Alves (著者), Renar Pereira Santos Pereira (著者)
• フォーマット: 図書
• 出版事項: University of Huddersfield Press, 2019-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The aim of this study was to engineer a DTG particle size able to provide plasma drug concentration maintenance above PA-IC-90 and, based on such drug prolonged- exposure, to evaluate the 30 days-acting injectable DTG feasibility for anti-HIV therapy. Liquid antisolvent precipitation technology was...