A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes

• Glavni autori: Lingxiao Wang (Autor), Haoqing Yang (Autor), Chen Zhang (Autor), Yue Zhang (Autor), Yilin He (Autor), Yang Liu (Autor), Pan Ma (Autor), Jun Li (Autor), Zhipeng Fan (Autor)
• Format: Knjiga
• Izdano: Nature Publishing Group, 2024-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Blood glucose fluctuation leads to poor bone defect repair in patients with type 2 diabetes (T2DM). Strategies to safely and efficiently improve the bone regeneration disorder caused by blood glucose fluctuation are still a challenge. Neutral sphingophospholipase 2 (Smpd3) is downregulated...