A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes

• Main Authors: Lingxiao Wang (Author), Haoqing Yang (Author), Chen Zhang (Author), Yue Zhang (Author), Yilin He (Author), Yang Liu (Author), Pan Ma (Author), Jun Li (Author), Zhipeng Fan (Author)
• Format: Book
• Published: Nature Publishing Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Blood glucose fluctuation leads to poor bone defect repair in patients with type 2 diabetes (T2DM). Strategies to safely and efficiently improve the bone regeneration disorder caused by blood glucose fluctuation are still a challenge. Neutral sphingophospholipase 2 (Smpd3) is downregulated...