A blood glucose fluctuation-responsive delivery system promotes bone regeneration and the repair function of Smpd3-reprogrammed BMSC-derived exosomes

• Автори: Lingxiao Wang (Автор), Haoqing Yang (Автор), Chen Zhang (Автор), Yue Zhang (Автор), Yilin He (Автор), Yang Liu (Автор), Pan Ma (Автор), Jun Li (Автор), Zhipeng Fan (Автор)
• Формат: Книга
• Опубліковано: Nature Publishing Group, 2024-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Blood glucose fluctuation leads to poor bone defect repair in patients with type 2 diabetes (T2DM). Strategies to safely and efficiently improve the bone regeneration disorder caused by blood glucose fluctuation are still a challenge. Neutral sphingophospholipase 2 (Smpd3) is downregulated...