The Impact of Single Nucleotide Polymorphisms on the Pharmacokinetics of Tacrolimus in Kidney Allograft Recipients of Northern-West, Iran

• Main Authors: Elaheh Jabbari Hagh (Author), Ali Mousavi (Author), Seyyedeh Mina Hejazian (Author), Mehdi Haghi (Author), Samaneh Esfahanian (Author), Elham Ahmadian (Author), Sepideh Zununi Vahed (Author), Mohammadreza Ardalan (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Calcineurin inhibitors (CNIs) such as tacrolimus are a major immunosuppressive therapy after renal transplantation, which inhibit cytokine expression. The pharmacokinetics of such drugs is influenced by cytochrome P450 (CYP) enzymes, multi-drug resistance-1 (MDR-1), and C25385T pregnane X r...