The Impact of Single Nucleotide Polymorphisms on the Pharmacokinetics of Tacrolimus in Kidney Allograft Recipients of Northern-West, Iran

• Päätekijät: Elaheh Jabbari Hagh (Tekijä), Ali Mousavi (Tekijä), Seyyedeh Mina Hejazian (Tekijä), Mehdi Haghi (Tekijä), Samaneh Esfahanian (Tekijä), Elham Ahmadian (Tekijä), Sepideh Zununi Vahed (Tekijä), Mohammadreza Ardalan (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Tabriz University of Medical Sciences, 2023-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Purpose: Calcineurin inhibitors (CNIs) such as tacrolimus are a major immunosuppressive therapy after renal transplantation, which inhibit cytokine expression. The pharmacokinetics of such drugs is influenced by cytochrome P450 (CYP) enzymes, multi-drug resistance-1 (MDR-1), and C25385T pregnane X r...