Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2

• Hoofdauteurs: Zhaoxia Zhang (Auteur), Wenjun Deng (Auteur), Rui Kang (Auteur), Min Xie (Auteur), Timothy Billiar (Auteur), Haichao Wang (Auteur), Lizhi Cao (Auteur), Daolin Tang (Auteur)
• Formaat: Boek
• Gepubliceerd in: BMC, 2016-03-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Sepsis is characterized by dysregulated systemic inflammation with release of early (for example, Interleukin (IL)-1β) and late (for example, HMGB1) proinflammatory mediators from macrophages. Plumbagin, a medicinal plant-derived naphthoquinone, has been reported to exhibit antiinflammatory...