Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2

• Main Authors: Zhaoxia Zhang (Author), Wenjun Deng (Author), Rui Kang (Author), Min Xie (Author), Timothy Billiar (Author), Haichao Wang (Author), Lizhi Cao (Author), Daolin Tang (Author)
• Format: Book
• Published: BMC, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Sepsis is characterized by dysregulated systemic inflammation with release of early (for example, Interleukin (IL)-1β) and late (for example, HMGB1) proinflammatory mediators from macrophages. Plumbagin, a medicinal plant-derived naphthoquinone, has been reported to exhibit antiinflammatory...