Dominant cross-reactive B cell response during secondary acute dengue virus infection in humans.

• Main Authors: Simona Zompi (Author), Magelda Montoya (Author), Marie O Pohl (Author), Angel Balmaseda (Author), Eva Harris (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The four serotypes of dengue virus (DENV) cause dengue fever (DF) and dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Severe disease has been associated with heterotypic secondary DENV infection, mediated by cross-reactive antibodies (Abs) and/or cross-reactive T cells. The role of cross-r...