A yeast model for amyloid-β aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity

• Glavni autori: Fabien D'Angelo (Autor), Hélène Vignaud (Autor), Julie Di Martino (Autor), Bénédicte Salin (Autor), Anne Devin (Autor), Christophe Cullin (Autor), Christelle Marchal (Autor)
• Format: Knjiga
• Izdano: The Company of Biologists, 2013-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

SUMMARY Alzheimer's disease is the most common neurodegenerative disease, associated with aggregation of amyloid-β (Aβ) peptides. The exact mechanism of neuronal cell dysfunction in Alzheimer's disease is poorly understood and numerous models have been used to decipher the mechanisms leadi...