A yeast model for amyloid-β aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity

• Main Authors: Fabien D'Angelo (Author), Hélène Vignaud (Author), Julie Di Martino (Author), Bénédicte Salin (Author), Anne Devin (Author), Christophe Cullin (Author), Christelle Marchal (Author)
• Format: Book
• Published: The Company of Biologists, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Alzheimer's disease is the most common neurodegenerative disease, associated with aggregation of amyloid-β (Aβ) peptides. The exact mechanism of neuronal cell dysfunction in Alzheimer's disease is poorly understood and numerous models have been used to decipher the mechanisms leadi...