Emerging Effects of Sepantronium Bromide (YM155) on MOLT-4 Cell Line Apoptosis Induction and Expression of Critical Genes Involved in Apoptotic Pathways

• Main Authors: Kobra Shojaei Moghadam (Author), Majid Farshdousti Hagh (Author), Mohammad Reza Alivand (Author), Masoumeh Fardi (Author), Ali Akbar Movassaghpour (Author), Ali Mohammadi (Author), Maryam Moghadasi (Author), Saeed Solali (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Sepantronium bromide (YM155) is a Survivin inhibitor which recently advanced as an anticancer agent in phase II clinical trials. Survivin belongs to IAP (inhibitor of apoptosis) gene family and is a pivotal target for treatment due to its overexpression and oncogenic function in many malign...