Emerging Effects of Sepantronium Bromide (YM155) on MOLT-4 Cell Line Apoptosis Induction and Expression of Critical Genes Involved in Apoptotic Pathways

• المؤلفون الرئيسيون: Kobra Shojaei Moghadam (مؤلف), Majid Farshdousti Hagh (مؤلف), Mohammad Reza Alivand (مؤلف), Masoumeh Fardi (مؤلف), Ali Akbar Movassaghpour (مؤلف), Ali Mohammadi (مؤلف), Maryam Moghadasi (مؤلف), Saeed Solali (مؤلف)
• التنسيق: كتاب
• منشور في: Tabriz University of Medical Sciences, 2020-01-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Purpose: Sepantronium bromide (YM155) is a Survivin inhibitor which recently advanced as an anticancer agent in phase II clinical trials. Survivin belongs to IAP (inhibitor of apoptosis) gene family and is a pivotal target for treatment due to its overexpression and oncogenic function in many malign...