Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications

• Main Authors: Miriam Pacetti (Author), Laura De Conti (Author), Luciano E. Marasco (Author), Maurizio Romano (Author), Mohammad M. Rashid (Author), Martina Nubiè (Author), Francisco E. Baralle (Author), Marco Baralle (Author)
• Format: Book
• Published: The Company of Biologists, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cellular level of TDP-43 (also known as TARDBP) is tightly regulated; increases or decreases in TDP-43 have deleterious effects in cells. The predominant mechanism responsible for the regulation of the level of TDP-43 is an autoregulatory negative feedback loop. In this study, we identified an i...