Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications

• Egile Nagusiak: Miriam Pacetti (Egilea), Laura De Conti (Egilea), Luciano E. Marasco (Egilea), Maurizio Romano (Egilea), Mohammad M. Rashid (Egilea), Martina Nubiè (Egilea), Francisco E. Baralle (Egilea), Marco Baralle (Egilea)
• Formatua: Liburua
• Argitaratua: The Company of Biologists, 2022-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The cellular level of TDP-43 (also known as TARDBP) is tightly regulated; increases or decreases in TDP-43 have deleterious effects in cells. The predominant mechanism responsible for the regulation of the level of TDP-43 is an autoregulatory negative feedback loop. In this study, we identified an i...