Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H₂O₂- and Aβ_1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells

• Main Authors: Ana M. de Matos (Author), Alice Martins (Author), Teresa Man (Author), David Evans (Author), Magnus Walter (Author), Maria Conceição Oliveira (Author), Óscar López (Author), José G. Fernandez-Bolaños (Author), Philipp Dätwyler (Author), Beat Ernst (Author), M. Paula Macedo (Author), Marialessandra Contino (Author), Nicola A. Colabufo (Author), Amélia P. Rauter (Author)
• Format: Book
• Published: MDPI AG, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency. Here, we were inspired by the widely reported potential of na...