Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis

• Hoofdauteurs: Ryan P. Trombetta (Auteur), Mark J. Ninomiya (Auteur), Ihab M. El-Atawneh (Auteur), Emma K. Knapp (Auteur), Karen L. de Mesy Bentley (Auteur), Paul M. Dunman (Auteur), Edward M. Schwarz (Auteur), Stephen L. Kates (Auteur), Hani A. Awad (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2019-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Osteomyelitis is a chronic bone infection that is often treated with adjuvant antibiotic-impregnated poly(methyl methacrylate) (PMMA) cement spacers in multi-staged revisions. However, failure rates remain substantial due to recurrence of infection, which is attributed to the poor performance of the...