Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis

• Main Authors: Ryan P. Trombetta (Author), Mark J. Ninomiya (Author), Ihab M. El-Atawneh (Author), Emma K. Knapp (Author), Karen L. de Mesy Bentley (Author), Paul M. Dunman (Author), Edward M. Schwarz (Author), Stephen L. Kates (Author), Hani A. Awad (Author)
• Format: Book
• Published: MDPI AG, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteomyelitis is a chronic bone infection that is often treated with adjuvant antibiotic-impregnated poly(methyl methacrylate) (PMMA) cement spacers in multi-staged revisions. However, failure rates remain substantial due to recurrence of infection, which is attributed to the poor performance of the...