Nav1.8 neurons are involved in limiting acute phase responses to dietary fat

• Main Authors: Swalpa Udit (Author), Michael Burton (Author), Joseph M. Rutkowski (Author), Syann Lee (Author), Angie L. Bookout (Author), Philipp E. Scherer (Author), Joel K. Elmquist (Author), Laurent Gautron (Author)
• Format: Book
• Published: Elsevier, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective and methods: Metabolic viscera and their vasculature are richly innervated by peripheral sensory neurons. Here, we examined the metabolic and inflammatory profiles of mice with selective ablation of all Nav1.8-expressing primary afferent neurons. Results: While mice lacking sensory neurons...